+1 Red Heart container.

Requires three of the following items :

Grants a heart container.

Requires 3 puberty pills

Roughly 25% of the time, Isaac shoots an extra tear, like 20/20 item.

Requires three of the following items :

Gives +2 damage and +0.15 speed, and spawns a random pill upon transformation.

Requires three of the following items :

Replaces Bum Friend, Dark Bum, and Key Bum for Super Bum. This bum collects any of the other beggars' pickups, and offers twice the rewards.

Requires three of the following items :

Isaac gains a green trail of poisonous creep.

Requires three of the following items :

Whenever a pile of poop is destroyed, health is replenished by half a heart.

Requires three of the following items :

Grants flight and gives +2 black hearts.

Requires three of the following items :

Grants flight and spawns a Blue Fly 50% of the time a tear hits an enemy.

Requires three of the following items :

or trinket :

Grants flight and gives +3 soul hearts.

Requires three of the following items :

Isaac gains a stationary knife that trails directly behind him. It synergizes like Mom's Knife would.

Requires three of the following items :

Spawns a spider familiar that applies random status effects to enemies it comes in contact with.

Requires three of the following items :

Grants flight and converts small enemy flies into Blue Flies.

Requires three of the following items :

When attacking, the tumor faces shoot tears diagonally outwards, similar to the effect of The Wiz. Also gives -0.3 damage and slightly decreases tears.

Requires three of the following items :

Upon getting three items or pills that increase Isaac's size, he will create dust clouds when walking and have a chance to spawn rock waves around him upon taking damage.

Requires three of the following items :

and One Makes You Larger pill